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   Table of Contents - Current issue
July-December 2020
Volume 3 | Issue 2
Page Nos. 35-56

Online since Monday, May 30, 2022

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Immunomodulators in Siddha system of medicine p. 35
K Kanakavalli
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An overview of Vatha Sura Kudineer (VSK): A potential Siddha antiviral drug p. 37
Shunmugaram Shenbagaraj, Lavanya Alagusolaiyan, Rajendra Kumar Arumugam
Introduction: The World Health Organization defines that communicable diseases are caused by microorganisms, fungi, insect bites, or contaminated water that can spread directly or indirectly, between persons. Chikungunya is an epidemic-prone vector-borne communicable disease caused by chikungunya virus (CHIKV). Due to the lack of appropriate treatment and vaccination, symptomatic or supportive treatments such as antipyretics, oral and tropical analgesics, and long-term anti-inflammatory therapy are the choices to manage chikungunya. This review aims to emphasize the potential role of a poly herbal Siddha formulation “Vatha Sura Kudineer (VSK)” used for the management of viral diseases in Siddha. Materials and Methods: The scientific details including morphological description, phytochemical constituents, and their pharmacological studies along with Siddha perspectives were collected from books and published journals. Results: This article provides comprehensive information of the ingredients of VSK, and it revealed their antiviral, antipyretic, anti-inflammatory, analgesic, antimicrobial, immunomodulatory, and antioxidant properties. Piperine and gingerol are the natural bioenhancers present in Piper longum Linn. and Zingiber officinale Roscoe, which may be enhancing the absorption and bioavailability of the formulation. Conclusion: As there is a lack of effective antiviral and anti-inflammatory drugs for the treatment of Chikungunya, VSK would be a cost effective, potent drug which needs to be explored.
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Retrospective time to event analysis of integrated medicine treatment effect on mild symptomatic COVID19 patients in facility quarantine at Kallakurichi, Tamil Nadu p. 45
Chinnasamy Prabu, Paneerselvam Parthiban, S Ganesh, Kanakavalli Kadaikarai, Angappan Sureshkumar, Sathiyarajeswaran Parameswaran, Nalupalil Purushothamam Vinod, Kiran Gurrala, Shanmugam Sangeetha, Ramamoorthy Mala, Periyasamy Sathya
Background: This study has been conducted on confirmed COVID 19 positive patients (n = 55), who had come to Kallakurichi District of Tamilnadu state from one of the containment zones in Indian State of Maharashtra. Out of the 55, 8 (14.55%) patients were symptomatic and remaining 47 (85.45%) were asymptomatic patients. 47 patients who reached in their home land on 24th May and rest on 25th may 2020. All of them have been treated with integrated medicine treatment method. Materials and Methods: Everybody was quarantined from 27th may to 7th June 2020 at Mahabharathi Engineering College, Vasudevanur, Chinna salem Taluk, Kallakurichi District. Integrative Intervention Consisting of Vitamin C Tablet, Zinc tablet for 5 days, and Kabasura Kudineer 60 ml BD Before food for all days was the treatment given for all patients. Result: Among them, three of them had co -morbid conditions like diabetes and hypertension. 27.3% were female and 72.7% are male patients. Average age was 32.33 among the range of 14 to 65years. Conclusion: All patients including who has co-morbidity were completely relieved from the disease on the day of discharge. All symptomatic patients were asymptomatic with median time of 4 days IP admission.
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Documentation and scientific validation of a Siddha ethnic practice Suttigai (cauterization) in Pudukottai district p. 48
Senthilkumar Vadivel, Chitra Balasubramanian, Gowsalya Ezhumalai, Nagalakshmi Muthumalai, Jayapriya Jayaraman
Introduction: Siddha system of medicine deals with the surgical as well as external application methods that are categorized under Pura Maruthuvam. In Siddhar Aruvai Maruthuvam, 32 types of treatment methods such as Kattu muraikal (splints), keeral (blood-letting), Komburinjal (Type of blood-letting through horns), and Attai vidal (Leech therapy) are described. The external therapy Suttigai (Cauterization) method is being practiced by Siddha physicians to cure chronic ailments which the internal drugs alone do not cure. There are many number of suttigai methodologies specified in Siddha Literatures and through inheritance by folklore practitioners. Materials and Methods: This study aimed to document the procedure of suttigai practiced by a traditional healer family in Pudukottai district, Tamil Nadu, which was being taught through their inheritance. They used to treat children with chest wall deformity in their surroundings for many generations. Results: The practitioner claims that as witnessed through their indigenous suttigai practices the treated children have not shown any significant post-treatment complications. The chest wall deformity is being rectified spontaneously along with the cauterized wound reconciliation. An image of a male aged 76 years, who was treated by his father of the practitioner, had a scar in his chest which was done at his age of 2 years for the congenital chest wall abnormality is illustrated here. Conclusion: In this paper, we attempt to substantiate the scientific rationale behind the traditional suttigai practice.
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The importance of power analysis and effect size in preclinical rodent experimentation p. 53
Krishnamurthy Venkataraman
Introduction: The quest for identification of novel compounds to treat disease conditions involves the conduct of proof of concept studies in laboratory animals. The experimental design often does not justify the animal numbers distributed across the various groups in an experiment. Materials and Methods: The prejudice to use a sample size 6 across all groups is out of sheer misconception that it can effectively inform the success of a treatment intervention. The statisticians however do not recommend the reliance on this misconceived notion and recommend the conduct of the power analysis for every biological experiment. Results: By employing power analysis, incorporating the effect size the sample size achieved can effectively prevent an experiment suffering from Type II error. The type II errors can frequently occur and can go unnoticed in biological experiments when novel treatments are tested. Conclusion: It therefore becomes a moral responsibility of an investigator to employ power analysis to estimate the sample size which can also benefit the investigator by alerting the investigator in not choosing more than recommended sample size which can result in saving monetary and manpower resources.
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