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 Table of Contents  
ORIGINAL RESEARCH
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 45-47

Retrospective time to event analysis of integrated medicine treatment effect on mild symptomatic COVID19 patients in facility quarantine at Kallakurichi, Tamil Nadu


1 Ayush Medical officer (Siddha), GPHC, Vadaponparappi, Villupuram District, Tamil Nadu, India
2 Joint Director of Indian Medicine and Homeopathy, Chennai, Tamil Nadu, India
3 Director of Indian Medicine & Homeopathy, Chennai, Tamil Nadu, India
4 Director General, Central Council for Research in Siddha, Chennai, Tamil Nadu, India
5 Assistant Medical Officer (S), GPHC, Kachirayapalaiyam, Villupuram District, Tamil Nadu, India
6 Director I/C Siddha Central Research Institute, Chennai, Tamil Nadu, India
7 Statistical Assistant, Siddha Central Research Institute, Chennai, Tamil Nadu, India
8 District Collector, Kallakurichi, Tamil Nadu, India
9 District Revenue Officer, Kallakurichi District, Tamil Nadu, India
10 District Siddha Medical Officer, Villupuram & Kallakurichi Districts, Tamil Nadu, India
11 Assistant Medical Officer (S), Government Hospital, Chinnasalem, Kallakurichi District, Tamil Nadu, India

Date of Submission26-Mar-2022
Date of Acceptance28-Mar-2022
Date of Web Publication30-May-2022

Correspondence Address:
Dr. Sathiyarajeswaran Parameswaran
Director I/C, Siddha Central Research Institute, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrsm.jrsm_8_22

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  Abstract 

Background: This study has been conducted on confirmed COVID 19 positive patients (n = 55), who had come to Kallakurichi District of Tamilnadu state from one of the containment zones in Indian State of Maharashtra. Out of the 55, 8 (14.55%) patients were symptomatic and remaining 47 (85.45%) were asymptomatic patients. 47 patients who reached in their home land on 24th May and rest on 25th may 2020. All of them have been treated with integrated medicine treatment method.
Materials and Methods: Everybody was quarantined from 27th may to 7th June 2020 at Mahabharathi Engineering College, Vasudevanur, Chinna salem Taluk, Kallakurichi District. Integrative Intervention Consisting of Vitamin C Tablet, Zinc tablet for 5 days, and Kabasura Kudineer 60 ml BD Before food for all days was the treatment given for all patients.
Result: Among them, three of them had co -morbid conditions like diabetes and hypertension. 27.3% were female and 72.7% are male patients. Average age was 32.33 among the range of 14 to 65years.
Conclusion: All patients including who has co-morbidity were completely relieved from the disease on the day of discharge. All symptomatic patients were asymptomatic with median time of 4 days IP admission.

Keywords: Co-morbidity, integrative treatment, Kabasura kudineer, Siddha medicine, survival analysis


How to cite this article:
Prabu C, Parthiban P, Ganesh S, Kadaikarai K, Sureshkumar A, Parameswaran S, Purushothamam Vinod N, Gurrala K, Sangeetha S, Mala R, Sathya P. Retrospective time to event analysis of integrated medicine treatment effect on mild symptomatic COVID19 patients in facility quarantine at Kallakurichi, Tamil Nadu. J Res Siddha Med 2020;3:45-7

How to cite this URL:
Prabu C, Parthiban P, Ganesh S, Kadaikarai K, Sureshkumar A, Parameswaran S, Purushothamam Vinod N, Gurrala K, Sangeetha S, Mala R, Sathya P. Retrospective time to event analysis of integrated medicine treatment effect on mild symptomatic COVID19 patients in facility quarantine at Kallakurichi, Tamil Nadu. J Res Siddha Med [serial online] 2020 [cited 2022 Aug 16];3:45-7. Available from: http://www.jrsm.in/text.asp?2020/3/2/45/346339


  Introduction Top


Globally several studies were initiated in all medical fields to cure the pandemic. Before vaccine development repurposing and revalidation of available medication has used for treating patients affected by Corona novel virus.[1] Traditional medicine world over also had its share on treating COVID 19. Govt of India has released Guidelines for treating COVID 19 using Indian traditional medicines on March 6th, 2020. Govt of Tamilnadu, released Aarokyam scheme[2] to treat COVID19 cases which advocated the use of Siddha medicine. COVID 19 made a platform for integrative treatment approaches worldwide. In National health policy 2017, India strongly recommended integrative treatment approaches. This is an observational study using integrated treatment approach on COVID 19 positive patients with Standard allopathic and Siddha medications.[3],[4]

COVID-19 is a new strain of coronavirus that has not been previously identified in humans. The COVID-19 is the cause of an outbreak of respiratory illness first detected in Wuhan, Hubei province, China. Coronaviruses are a large family of viruses that are known to cause illness ranging from the common cold to more severe diseases such as Severe Acute Respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS).[5]

A confirmed case was defined by epidemiological history and/or clinical features that a suspected case may contact with COVID-19 infected persons and/or had symptoms and signs of COVID-19 infection, plus positive laboratory test including virus nucleic acid, gene sequencing and serum antibody detection.

Following first ever reported case in Wuhan in December, 2019, PHEI (Public Health Emergency of International concern) announced by WHO in January. There are several studies in all medical fields to cure the COVID 19 pandemic Corona Virus. National Health Policy recommended Integrative medicine treatment approach. COVID 19 a platform for integrative treatment approaches since National health policy, India strongly recommended integrative treatment approaches. India declared an emergency alert in March 2020. Kabasura kudineer found its place in the advisory of Ministry of Ayush. long with this Zinc and Vitamin c is advocated by Tamilnadu government, Administration of Kallakurichi District – Chinna Salem took a positive step to contain COVID19 through Integrated approaches. In this regard the benefit offered by Integrated Medicine -Zinc, Vitamin C and Kabasura Kudineer (ZVcKK) is evaluated.[6] This is an observational study using integrated treatment approach on COVID 19 positive patients.


  Ethics Top


The personal identifiers such as name and address of the patient’s records were removed to ensure the confidentiality and anonymity. Collection of information regarding the age, gender, address and all other information collected from patients were also kept confidential. The study has been approved by Institutional Ethics Committee of Government Siddha Medical College, Chennai.


  Methodology Top


Data collected from confirmed COVID-19 positive cases reported to Kallakurichi District of Tamilnadu state from one of the containment zones in Indian State of Maharashtra. Everybody was quarantined from 27th may to 7th June 2020 at Mahabharathi Engineering College, Vasudevanur, Chinna salem Taluk, Kallakurichi District.

Treatment

Vitamin C Tablet and Zinc tablet for 5 days and Kabasura Kudineer 60 ml BD Before food in all days was the treatment given for all patients.

Definitions

A confirmed case was defined by epidemiological history and/or clinical features that a suspected case may contact with COVID-19 infected persons and/or had symptoms and signs of COVID-19 infection, plus positive laboratory test including virus nucleic acid, gene sequencing and serum antibody detection.

Statistical analysis

Descriptive statistical analysis and Kaplan Meier survival analysis[7] was carried out using Statistical Package for Social Sciences (SPSS) software.


  Results Top


Gender

Out of the 55 cases, 15(27.3%) female and 40(72.7%) male cases [Table 1], it is clear that there is no gender equality.
Table 1: Gender Distribution

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Age

The study belongs to the patients from age 14 to 65. Average age is 32.33, median age is 30 and most frequently occurring age is 25 [Figure 1].
Figure 1: Percentage wise Age Group Distribution

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It is clear that highest percentage of 33% belongs to age group 21–30 and second highest of 29% belongs to 31–40 group and third highest of 18% belongs to 11–20 group and least percentage of 7% belongs to 51–70 age group.

Symptoms

Out of the 55, only 14.5% had symptoms during the study period. 10.9% (6) cases had cold and 3.6% (2) cases reported to have cough [Table 2].
Table 2: Cases having Symptoms and No. of Days taken for Recovery

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Time to event analysis of the 8 symptomatic cases were performed, and all the 8 cases became asymptomatic after some days of treatment. Symptomatic cases became asymptomatic after treatment was treated as events else considered as censored; hence all cases were treated as events in the study.

There was no significant difference in the survival time of the two symptomatic cases became asymptomatic (Log-rank statistic = 0.156, df = 1, P = 0.693). The average survival time is 3.63 days and median survival time is 4 days [Table 3] and all patients were discharged on 10th day as per revised discharge Policy.[8]
Table 3: Descriptive Statistics of Survival Data (SPSS Output of Kaplan- Meier Estimator)

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Comorbid condition

Only 5.45% of cases (10) have co-morbid conditions present, remaining 94.55% are free from co-morbid diseases. Diabetes mellitus and Hyper tension were the comorbid condition reported. One patient belonging to 41 to 50 age group had High BP and Increased Blood sugar levels and Moderate BPand DM patient belongs to age group 51–70.


  Conclusion Top


All 55 cases were reported to be COVID 19 positive in the beginning of the study. All the patients who got reduction in symptoms were discharged as per revised discharge policy of Ministry of Health and Family Welfare, GoI. assumed to be COVID 19 negative at the end of the study after giving treatment of Vitamin C Tablet and Zinc tablet for 5 days and Kabasura Kudineer 60 ml BD Before food for all days. All symptomatic patients became asymptomatic with median time of 4 days. The study panel came to the assumption of the result because of all of the symptomatic patients are asymptomatic on the discharge date and all asymptomatic patients retained good health.

Acknowledgement

The authors would like to thank Dr. Shree Devi M.S, R.O(S), Siddha Central Research Institute for her support in this Manuscript.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World health organization declares global emergency: A review of the 2019 novel coronavirus (Covid-19). Int J Surg 2020;76:71-6.  Back to cited text no. 1
    
2.
Abstract, Indian Medicine and Homeopathy – “AAROKYAM” Special Programme with AYUSH interventions for COVID-19-Implementation – Orders Issued – Health and Family Welfare (IM1- 1) Department G.O.(Ms).No.201 Dated 23.04.2020  Back to cited text no. 2
    
3.
Rathinam S, Muthiah K, Parameswaran S, Tamilarasan K, Selvarajan E, Ayyasamy U. Analogy of Kaba Suram A Siddha Literature Review. International Journal of Ayurvedic Medicine 2020;11:616-21.  Back to cited text no. 3
    
4.
Ganapathy AA, Kumaran A, Lekha GS. Prevention of COVID 19 - Siddha perspective. International Journal of Ayurvedic Medicine 2020;11:594-615.  Back to cited text no. 4
    
5.
Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol 2020;92:401-2.  Back to cited text no. 5
    
6.
Jamuna D, Sathiyarajeswaran P, Devi MS, Kanakavalli K, Vinod NP, Nirmala A. et al. Survival analysis to assess the length of stay of novel coronavirus (COVID-19) patients under Integrated Medicine - Zinc, Vitamin C & Kabasura Kudineer (ZVcKK). EJMCM 2021;7:1375-87.  Back to cited text no. 6
    
7.
Langova K. Survival analysis for clinical studies. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2008;152:303-7.  Back to cited text no. 7
    
8.
Natarajan S, Anbarasi C, Sathiyarajeswaran P, Manickam P, Geetha S, Kathiravan R, et al. The efficacy of siddha medicine, Kabasura Kudineer (Ksk) compared to vitamin C & zinc (Cz) supplementation in the management of asymptomatic Covid-19 cases: A structured summary of a study protocol for a randomised controlled trial. Trials 2020;21:892.  Back to cited text no. 8
    


    Figures

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    Tables

  [Table 1], [Table 2], [Table 3]



 

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