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Year : 2018  |  Volume : 1  |  Issue : 1  |  Page : 68-71

In Vitro Anthelmintic Activity of Achyranthes aspera Linn. (Whole Plant) Against Pheretima posthuma

1 Department of Biochemistry, SRM Arts and Science College, Kattankulathur, Tamil Nadu, Pincode -603203, India
2 Siddha Regional Research Institute (CCRS), Kuyavarpalayam, Puducherry, Pincode - 6050T3, India

Correspondence Address:
Gayathri Gunalan
Siddha Regional Research Institute (CCRS), Kuyavarpalayam, Puducherry, Pincode - 6050T3
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Source of Support: None, Conflict of Interest: None

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Introduction: Helminthiasis or worm infestation is one of the most prevalent diseases in the world. It is one of the most serious problems in the developing countries. Anthelmintic plants are used traditionally to treat parasitic infections. Achyranthes aspera (Amaranthaceae) is an important medicinal plant found as a weed throughout India and tropical Asia. The aim of the present study was to evaluate the anthelmintic activity of A. aspera against Pheretima posthuma (earthworm). Methods: The anthelmintic activity was evaluated on adult Indian earthworms by reported methods. Results: The anthelmintic activity was studied using ethyl acetate, ethanol and aqueous extracts of the whole plant at a test concentration of 25, 50, 75 and 100 mg/ml each. Albendazole was used as standard. All the three extracts have exhibited significant dose dependent anthelmintic activity at the tested dose level. Aqueous extract was found to have better activity followed by ethyl acetate extract and the least activity was reported for ethanol extract. Conclusion: Thus from the present study, it can be concluded that A.aspera extracts (Aqueous>Ethyl acetate> Ethanol) have potent anthelmintic activity when compared with the conventional drug, albendazole. Further studies are required to isolate the active principles and also to establish the pharmacological rationale for the anthelmintic activity of A. aspera.

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